Dynamic small forward Cody Weightman has broken his collarbone on a "night of carnage" for the Western Bulldogs, coach Luke Beveridge said.

Weightman tried to lay a big bump on Port Adelaide ruckman Sam Hayes early in the last quarter of Friday night's 17-point loss and came off with the worst possible result.

He was not the only Bulldog to leave Adelaide Oval early, with speedster Laitham Vandermeer suffering a "high grade" hamstring injury and defender Tim O'Brien a calf injury.

Both men left the ground before three-quarter time.

Beveridge was philosophical about the setbacks, however he said the short turnaround from Sunday's win over Essendon might have played a role in two of the injuries.

"It was a disappointing night for us and a night of carnage for us too when you lose three players in the fashion we did," he said.

"The five-day break might have got us a little bit with some of that unfortunately.

"It was high-end running the week before against Essendon and one or two of the guys in Tim O'Brien and Laitham, who are quite prone, went down, so that destabilised us a little bit."

Beveridge said the severity of each injury would be confirmed in the coming days, but he was making no excuses for his team, which now has a 3-5 win-loss record.

He did offer some hope ahead of next Friday night's match against Collingwood at Marvel Stadium though, saying three big names were in the frame to return, led by skipper Marcus Bontempelli.

"We think he'll be ok. He's just had a series of things hampering him over a period of time that just came to a head this week," he said.

"The week off will do him the world of good, and hopefully he'll be healthy come Friday night, but we'll see how we go next week.

"Maybe Tim English and Alex Keath might be available.

"Clubs and teams go through it. We're getting our lot at the moment unfortunately. We've just got to ride it out and persevere."